A study of MLC1 and GlialCAM protein interactions identifies possible therapeutic targets. Beyond an important role in volume regulation and localization, there are still many unanswered questions about the exact function of MLC1 and GlialCAM. This paper seeks to answer this question by examining what proteins MLC1 and GlialCAM interact with. Importantly, these proteins were discovered to interact with two G-protein coupled receptors (GPCRs). GPCRs have important roles in signaling interactions in the body and are promising drug targets for future studies.