These four studies are the first to demonstrate a potential function of the MLC1 protein in regulating ion channels and transporters important for controlling ions and water homeostasis, which affects the volume of cells. These findings suggest that MLC may be caused by the fact that astrocytes in the brain are chronically swollen because of a defect in ion homeostasis.
2011: Paper 1, Paper 2
2012: Paper 3, Paper 4
