Category: Timeline Stories

Timeline Stories

First brain pathology examination of MLC

This is the first description of how MLC affects the brain. Brain white matter was studied. This study shows that in MLC the myelin is present in relatively normal quantities. However, the swelling of the white matter seen on MRI is reflected by the extensive presence of fluid-filled balloons (vacuoles) in the myelin at the..Read More

Timeline Stories

Dr. Singhal discovers MLC in India

Dr. Singhal independently discovered MLC in India and described the disease in 30 Indian patients, most of them belonging to the Agarwal community. Read paper

Timeline Stories

Dr. van der Knaap discovers MLC

This paper is the first to describe MLC in a group of eight patients. At this time, patients were diagnosed based on the brain MRI pattern and clinical characteristics, which are defined in this paper.   Read paper